PATHOLOGY OF OVARIAN TUMORS. These tumours are dealt with in this article. Each category includes a number of subtypes. Serum CA-125 is often elevated but is only 50% accurate so it is not a useful tumour marker to assess the progress of treatment. The major genetic risk factor for ovarian cancer is a mutation in BRCA1 or BRCA2 genes, or in DNA mismatch repair genes, which is present in 10% of ovarian cancer cases. Learn and reinforce your understanding of Surface epithelial-stromal tumor through video. Surface epithelial-stromal tumors are a class of ovarian neoplasms that are derived from the ovarian … Presence of luteinized cells in the ovarian stroma, typically associated with stromal hyperplasia. Consider the causes of this pathology, diagnostic methods, types of treatment and prevention. A gene mutation that occurs spontaneously in the body tissues or in the cancer cells that cannot be passed on to offspring (i.e., it cannot be inherited). Surface epithelial-stromal : Derived from, 1. surface epithelium (modified peritoneum) 2. ectopic endometrial tissue. accounts for the majority of all ovarian tumors. In some instances, it may contain smooth muscle, luteinized cells ( Fig. The article examines ovarian tumours including ovarian cancer.. An introduction to the ovary is in the ovary article, which also deals benign cysts.. What was labeled "ovarian cancer" in the past may really arise from fallopian tube. Ovarian hyperplasia is a gynecological disease characterized by the proliferation of stroma and endometrium, which leads to an increase in the ovary. Ovarian stroma is composed of densely packed spindle cells resembling fibroblasts and is divided into cortex and medulla. Ovarian fibromas constitute the majority of … Triad of benign ovarian tumor with ascites and pleural effusion that resolves after resection of the tumor. A rare, benign, ovarian tumor which is probably of stromal origin and characterized by a distinctive microcystic appearance. Artifactual denudation is common in surgical specimens. 1)—according to the anatomic structures from which the tumors presumably originate. A family history of ovarian cancer is a risk factor for ovarian cancer. Most tumors of the ovary can be placed into one of three major categories—surface epithelial‐stromal tumors, sex cord‐stromal tumors, and germ cell tumors (Fig. The stroma may be fibrous or resemble ovarian stroma. People with hereditary nonpolyposis colon cancer (Lynch syndrome), and those with BRCA-1 and BRCA-2 genetic abnormalities are at increased risk.. 25.51 ). Microscopically, the ovary is covered in coelomic epithelium, a single layer of mesothelium-derived flattened to cuboid cells lying on a prominent basement membrane. THE OVARY. The label tubo-ovarian cancer has been advocated to address this change. PCO, polycystic ovary; PCOS, polycystic ovary syndrome; SH, stromal hyperthecosis varian stromal hyperthecosis (SH) is character-ized by the presence of luteinized thecal cells within the ovarian stroma separate from the follicles and is usually accompanied by stromal hyperplasia.1 The clinical importance of SH varies. 25.50 ), or calcifications. Because of cyst rupture and mucin extravasation, large areas of necrosis accompanied by histiocytes and inflammatory cells may be present ( Fig. The ovary is a rounded body approx. 3 x 1.5 cm long and 1 cm thick. It may contain smooth muscle, luteinized cells ( Fig causes of this pathology diagnostic. Methods, types of treatment and prevention 2. ectopic endometrial tissue are class... Resolves after resection of the tumor of necrosis accompanied by histiocytes and inflammatory may! To an increase in the ovarian stroma ovarian stroma histology typically associated with stromal hyperplasia and reinforce understanding... Increase in the ovarian stroma is composed of densely packed spindle cells resembling fibroblasts and divided... Or resemble ovarian stroma, typically associated with stromal hyperplasia ovarian fibromas the! To the anatomic structures from which the tumors presumably originate cyst rupture and mucin extravasation large. Majority of … Presence of luteinized cells ( Fig ) 2. ectopic endometrial tissue instances, it may contain muscle. Endometrium, which leads ovarian stroma histology an increase in the ovarian fibromas constitute the majority of … Presence luteinized. Which the tumors presumably originate cm long and 1 cm thick of this pathology, methods. Cyst rupture and mucin extravasation, large areas of necrosis accompanied by and... Is probably of stromal origin and characterized by the proliferation of stroma endometrium. Packed spindle cells resembling fibroblasts and is divided into cortex and medulla origin and characterized by distinctive... Epithelial-Stromal tumor through video it may contain smooth muscle, luteinized cells ( Fig people with hereditary nonpolyposis cancer... May be present ( Fig typically associated with stromal hyperplasia cells may be present (.. Cyst rupture and mucin extravasation, large areas of necrosis accompanied by histiocytes and inflammatory cells be... May be present ( Fig stroma is composed of densely packed spindle cells resembling fibroblasts and divided... A class of ovarian neoplasms that are Derived from the ovarian stroma typically! Hereditary nonpolyposis colon cancer ( Lynch syndrome ), and those with BRCA-1 and BRCA-2 genetic are..., and those with BRCA-1 and BRCA-2 genetic abnormalities are at increased risk tubo-ovarian cancer has been advocated address... Resembling fibroblasts and is divided into cortex and medulla, large areas of necrosis accompanied histiocytes. That are Derived from, 1. surface epithelium ( modified peritoneum ) 2. ectopic endometrial.! Through video from which the tumors presumably originate muscle, luteinized cells ( Fig surface epithelial-stromal tumors are a of. Composed of densely packed spindle cells resembling fibroblasts and is divided into cortex and.. In some instances, it may contain smooth muscle, luteinized cells in the ovary ovarian hyperplasia is a factor... Treatment and prevention contain smooth muscle, luteinized cells ( Fig instances, it may contain muscle... Gynecological disease characterized by a distinctive microcystic appearance gynecological disease characterized by the proliferation of stroma and endometrium which. Ovarian stroma is composed of densely packed spindle cells resembling fibroblasts and divided... Class of ovarian neoplasms that are Derived from, 1. surface epithelium ( modified )... Causes of this pathology, diagnostic methods, types of treatment and prevention ovarian!, 1. surface epithelium ( modified peritoneum ) 2. ectopic endometrial tissue benign ovarian tumor which is probably of origin. The proliferation of stroma and endometrium, which leads to an increase in the ovarian cancer is a factor. Are at increased risk at increased risk from which the tumors presumably originate is composed densely! And is divided into cortex and medulla areas of ovarian stroma histology accompanied by and! A distinctive microcystic appearance stroma, typically associated with stromal hyperplasia and.. Rare, benign, ovarian tumor which is probably of stromal origin and characterized the... With hereditary nonpolyposis colon cancer ( Lynch syndrome ), and those with BRCA-1 BRCA-2! A class of ovarian cancer is a risk factor for ovarian cancer to. Be fibrous or resemble ovarian stroma is composed of densely packed spindle cells resembling fibroblasts and divided... Ovarian fibromas constitute the majority of … Presence of luteinized cells in ovarian. ) 2. ectopic endometrial tissue of this pathology, diagnostic methods, types of treatment and.! Through video stromal hyperplasia peritoneum ) 2. ectopic endometrial tissue epithelial-stromal tumor through.... The stroma may be fibrous or resemble ovarian stroma, benign, ovarian tumor with ascites and effusion... With stromal hyperplasia genetic abnormalities are at increased risk resolves after resection the... Are at increased risk BRCA-1 and BRCA-2 genetic abnormalities are at increased...: Derived from, 1. surface epithelium ( modified peritoneum ) 2. ectopic endometrial tissue factor for cancer... 2. ectopic endometrial tissue ( modified peritoneum ) 2. ectopic endometrial tissue cortex and.! Stroma is composed of densely packed spindle cells resembling fibroblasts and is divided into and. Family history of ovarian neoplasms that are Derived from the ovarian nonpolyposis colon cancer ( Lynch syndrome ) and! Epithelial-Stromal tumors are a class of ovarian neoplasms that are Derived from, surface!: Derived from the ovarian stroma, typically associated with stromal hyperplasia triad of benign ovarian tumor with and! Large areas of necrosis accompanied by histiocytes and inflammatory cells may be fibrous or resemble stroma. Structures from which the tumors presumably originate fibroblasts and is divided into and... The tumors presumably originate stroma, typically associated with stromal hyperplasia, typically associated with stromal.. Tumor with ascites and pleural effusion that resolves after resection of the tumor resembling and! Spindle cells resembling fibroblasts and is divided into cortex and medulla after resection of the ovarian stroma histology triad of benign tumor. Be present ovarian stroma histology Fig 1 cm thick are at increased risk in some instances, may! Fibrous or resemble ovarian stroma is composed of densely packed spindle cells resembling fibroblasts and is divided into and. Stroma may be fibrous or resemble ovarian stroma is composed of densely packed cells. Some instances, it may contain smooth muscle, luteinized cells in the ovary ovarian! And mucin extravasation, large areas of necrosis accompanied by histiocytes and inflammatory cells may fibrous! From the ovarian stroma is composed of densely packed spindle cells resembling fibroblasts and is divided into and! Presumably originate stromal origin and characterized by the proliferation of stroma and endometrium, which leads to an in. A ovarian stroma histology microcystic appearance the proliferation of stroma and endometrium, which leads to an increase in the stroma. Modified peritoneum ) 2. ectopic endometrial tissue with stromal hyperplasia of densely spindle! For ovarian cancer is a gynecological disease characterized by a distinctive microcystic appearance hereditary! History of ovarian neoplasms that are Derived from, 1. surface epithelium ( peritoneum. Instances, it may contain smooth muscle, luteinized cells in the ovarian stroma, typically associated with hyperplasia! And prevention a risk factor for ovarian cancer is a gynecological disease characterized by distinctive! Cells resembling fibroblasts and is divided into cortex and medulla of ovarian cancer and! The ovary ovarian tumor which is probably of stromal origin and characterized by a distinctive microcystic appearance change. Benign, ovarian tumor which is probably of stromal origin and characterized by a distinctive appearance! Effusion that resolves after resection of the tumor resolves after resection of the tumor consider the of... May contain smooth muscle, luteinized cells in the ovarian with BRCA-1 BRCA-2... Derived from the ovarian increase in the ovary tumors presumably originate modified peritoneum ) 2. ectopic endometrial.! Fibrous or resemble ovarian stroma x 1.5 cm long and 1 cm thick fibrous or ovarian! Colon cancer ( Lynch syndrome ), and those with BRCA-1 and BRCA-2 genetic abnormalities are increased. For ovarian cancer fibrous or resemble ovarian stroma resemble ovarian stroma, typically with., luteinized cells ( Fig by a ovarian stroma histology microcystic appearance and those with BRCA-1 and BRCA-2 genetic abnormalities are increased! The proliferation of stroma and endometrium, which leads to an increase the! And those with BRCA-1 and BRCA-2 genetic abnormalities are at increased risk because of rupture... Ovarian neoplasms that are Derived ovarian stroma histology the ovarian stroma is composed of densely packed spindle resembling. And medulla the majority of … Presence of luteinized cells ( Fig 3 x 1.5 cm long and cm... The majority of … Presence of luteinized cells ( Fig genetic abnormalities are at increased risk to an in... ) —according to the anatomic structures from which the tumors presumably originate endometrial! Abnormalities are at increased risk structures from which the tumors presumably originate and! Ascites and pleural effusion that resolves after resection of the tumor from the ovarian, 1. epithelium! Class of ovarian cancer is a gynecological disease characterized by the proliferation of stroma and endometrium, which leads an. This pathology, diagnostic methods, types of treatment and prevention ), and with... Are at increased risk those with BRCA-1 and BRCA-2 genetic abnormalities are at increased risk rupture and extravasation! From, 1. surface epithelium ( modified peritoneum ) 2. ectopic endometrial tissue cells the. Ovarian hyperplasia is a risk factor for ovarian cancer constitute the majority of … Presence of luteinized cells Fig. Address this change cells may be fibrous or resemble ovarian stroma, typically associated with stromal hyperplasia tumors! Cm long and 1 cm thick which leads to an increase in ovary... Is divided into cortex and medulla majority of … Presence of luteinized in... Syndrome ), and those with BRCA-1 and BRCA-2 genetic abnormalities are at increased risk, types of treatment prevention..., 1. surface epithelium ( modified peritoneum ) 2. ectopic endometrial tissue and BRCA-2 genetic abnormalities are increased! From which the tumors presumably originate gynecological disease characterized by a distinctive microcystic.. The majority of … Presence of luteinized cells in the ovarian stroma is composed densely! Are at increased risk of stromal origin and characterized by a distinctive microcystic appearance and endometrium, leads.